Mini Review: The Application of Omics in Targeted Anticancer Biopharmaceuticals Development

Cancer is a complex invasive genetic disease and a significant cause of mortality worldwide. To effectively treat cancer using targeted biopharmaceuticals, it is essential to uncover the biological functions of genes, proteins and metabolites underlying abnormal cancer cell growth. The highthroughput Omics technologies have been proved as efficient approaches to investigate the initiation, development, and progression of cancers. This article reviews the cancer Omics and its applications in targeted anticancer biopharmaceuticals development. We first discuss how the established Omics knowledge and integrated data mining tools have been used to discover cancer biomarkers that reveal the clinically relevant diagnoses, prognoses and therapies. Deciphering cancer drivers has led to the specific design of effective cancer therapeutic approaches such as those target specific regulator, core pathways, glycolysis, and mitochondria. The developments of targeted cancer therapy, biopharmaceutical, and personalized medicine facilitated by Omics technologies are then described. Development of therapeutic proteins to treat various cancers has been greatly benefited from the significant findings in cancer mechanism studies using Omics. For instance, the recent advances in CHOnomics have enabled the rational bio processing design to improve clinical efficiency of biopharmaceuticals. The potential applications of CHOnomics in Chinese hamster ovary (CHO) cell?based therapeutic proteins production are finally presented.