Development and Evaluation of Thermal-Sensitive Ferrofluids for Drug Delivery Exercise

Novel thermal-sensitive ferro?uids (F127-ferro?uids) consisting of core?shell-type magnetic nanoparticles dispersed in Pluronic F127- containing aqueous solution were prepared. The core (magnet)?shell (Pluronic F127) nanoparticles were synthesized by in situ co- precipitation process, which were characterized using transmission electron microscope, X-ray diffraction and vibrating sample magnetometer. The F127-ferro?uids gelled above the lower critical solution temperatures (LCST) of approximately 23?28 1C, which were higher than that of pure Pluronic F127-?uids (21?25 1C). The increase in the LCST of the F127 ferro?uids may be attributed to a result of a physical interaction between the F127 molecules and the core?shell magnetic nanoparticles.