One year surveillance of antimicrobial sensitivity pattern of different antibiotics on clinical isolates of Escherichia coli with comparison of resistance against different antibiotics in four major cities in Bangladesh
Journal: International Journal of Basic & Clinical Pharmacology (Vol.2, No. 5)Publication Date: 2013-10-01
Authors : Shamema Nasrin Fatema Tuz Zohera Sheikh Arman Mahbub Halima Akther Mahamudul Haque;
Page : 607-612
Keywords : Antibiotic Susceptibility; Resistance; E coli;
Abstract
Background: The aim of study was to provide supportive implications for proper treatment of E. coli induced infections and related complications regarding antibiotic resistance. Methods: Total 600 isolates of E. coli from four major cities of Bangladesh were included in studies which were isolated from clinical diagnostic facilities in Dhaka, Chittagong, Rajshahi and Khulna. The antimicrobial sensitivity test of each E. coli isolate to 16 antimicrobial agents was carried out by the Kirby-Bauser disc diffusion method. Results: In the present investigation, the most effective antimicrobial against E. coli was found to be antibiotics of Carbapenem group; Doripenem 98.67% sensitive in Dhaka and Chittagong, 100% sensitive at Rajshahi and Khulna, Meropenem 89.33, 92.67, 95.33 and 97.33%, Imipenem 84.00, 86.00, 95.33 and 97.33 in Dhaka, Chittagong, Rajshahi and Khulna respectively. Apart from these third generation antibiotics like Cefixime 80.00% (D), 78.67% (C),78.00% (R), 82.00% (K) and Ceftriaxone 78.00% (D), 76.67(C), 65.33(R), 66.67(K) were shown satisfactory amount of sensitivity against E. Coli. Our research reveals that in Bangladesh commonly used conventional older, common, cheaper antibiotics used against E. coli were shown alarming rate of resistance to E. coli strains. Among them Amoxicillin, Tetracycline, Cloxacillin and Nalidixic Acid showed more than 80% resistance in most of the areas. Most widely used antibiotic Ciprofloxacin has become 39.99 to 49.99% resistant. Conclusion: These findings suggest urgent need for creating greater public awareness about antibiotic. It is also important that healthcare providers effectively communicate with their patients, to improve treatment compliance and health outcomes. [Int J Basic Clin Pharmacol 2013; 2(5.000): 607-612]
Other Latest Articles
- Does chronic alcohol use by HIV-infected patients on d4T/3TC/NVP drug regimen effect the HIV viral load and what is the therapeutic window of the drugs, CD4+ count and WBC count in patients with high viral load during the 9 months period of follow up?
- Sensitivity pattern of bacteria causing respiratory tract infections in a tertiary care centre
- Pre- & post- bronchodilator pulmonary function test in Indian females: a survey in and around Jaipur
- Efficacy, tolerability and cost effectiveness of zotepine versus olanzapine in patients of acute schizophrenia
- Experimental evaluation of anticonvulsant effect of human placental extract in pentylenetetrazole induced convulsions in mice
Last modified: 2013-10-17 10:51:08