ADVERSE DRUG REACTION PATTERN OF ANTI PSYCHOTIC DRUGS PRESCRIBED IN PSYCHIATRY OUT-PATIENT DEPARTMENT IN A TERTIARY CARE HOSPITAL

OBJECTIVE-To study the pattern of adverse drug reactions of Anti psychotic drugs in patients attending the Psychiatry out- patient department at Rajiv Gandhi Government General Hospital .METHODOLOGY-400 patients attending psychiatry OPD were enrolled in the study. Duration of study was 2 months. Adverse drug reactions of Anti psychotic drugs were documented. Causality assessment of ADRs was done using WHO Causality assessment scale. Severity assessment was done using Modified Hartwig Siegel severity assessment scale.RESULTS-Most of the patients were in the age group of 31- 40 years. Males constituted 60 percentage and females 40 percentage of test population. Risperidone was the most commonly prescribed Anti psychotic drug. Among 400 patients, 236 patients developed adverse drug reaction . Sedation was the most common adverse drug reactions encountered with all the three drugs. Extrapyramidal symptoms (Tremors , Dystonia) were more common with Haloperidol and Chlorpromazine whereas weight gain was seen only with Risperidone. 53 percentage of ADRs come under probable category of WHO Causality assessment scale.95 percentage of ADRs fall under mild category o f s e v e r i t y a s s e s s m e n t scale .CONCLUSION- Risperidone was the most commonly prescribed Anti psychotic drug. Sedation was the most common adverse drug reaction encountered.Most of the ADRs were mild and comes under Probable category of WHO causality assessment scale.