ANTIBACTERIAL, ANTIOXIDANT AND CYTOTOXIC ACTIVITIES OF FICUS HISPIDA LEAVES AND FRUITS

The aim of conducting this study is to investigate the antibacterial, antioxidant and cytotoxic activities of the ethanolic leaf and fruit extracts of Ficus hispida to rationalize its primitive medicinal contemplation. F. hispida was subjected to bacterial inquisition by disc diffusion stratagemin opposition to Gram positive and Gram negative bacteria conducting kanamycin as standard. The leaf extract ascertained good antibacterial activity against Pseudomonas aeruginosa with 13 mm zone of inhibition and moderate activity against Bacillus cereus and Vibrio parahaemolyticus with 11mm and 10 mm zone of inhibition respectively. But the organisms were not sensitive to the fruit extract. Antioxidant activity of the plant was evaluated spectrophotometrically using DPPH and ascorbic acid as standard. The leaf and fruit extracts explicated significant antioxidant activity with the IC50 value of 41.68 μg/ml, 28.39 μg/ml successively compared with the standard ascorbic acid at 45.78 μg/ml. The cytotoxic activity of F. hispida was scrutinized by brine shrimp lethality bioassay utilizing vincristine sulfate as standard. The ethanolic leaves and fruits extract revealed auspicious cytotoxic activity with LC50 value of 10.32 μg/ml, 14.69μg/ml consecutively, inwhere; LC50 of Vincristine sulphate was 6.11 ?g/ml. This article may provide optimistic empirical data to fact-finders and it can be further outstretchedto disengage the bio-active components owing to determine the antioxidant as well as cytotoxic activity in human cell line. Key words: Ficus hispida, Antibacterial, Antioxidant, Cytotoxic activity.