A COMPARATIVE STUDY OF EFFICACY AND SAFETY OF RACEMIC SALBUTAMOL AND LEVOSALBUTAMOL IN PATIENTS WITH ASTHMA
Journal: Indian Journal of Medical Research and Pharmaceutical Sciences (Vol.3, No. 9)Publication Date: 2016-09-30
Authors : Ujwala P. Gawali; Agharia Makbool Ali Mikdad Ali;
Page : 68-75
Keywords : Asthma; Levosalbutamol; Racemic salbutamol.;
Abstract
Aim: The present study was conducted to compare the efficacy and safety of racemic salbutamol with levosalbutamol in patients of bronchial asthma Methods: A prospective, randomized, open label 8 weeks study. After taking informed consent of 100 patients of either sex were randomly divided in to racemic salbutamol ( group A) and levosalbutamol ( group B ) group of 50 patients each. At first visit ( 0 week) Spirometry parameters like FEV1, FVC, PEFR and heart rate changes were recorded before and 20 minutes after drug administration via MDI. Patients were prescribed the study drug for further 4 weeks for safety assessment. At 4 weeks spirometry parameters and heart rate changes were recorded before and 20 minutes after drug administration. At both the visits patients were interviewed for side effects. Results were analysed at 0 and 4 weeks. Result: At 0 and 4 weeks mean percentage increase of FEV1, FVC, PEFR in levosalbutamol group after drug administration was significantly higher. Conclusion: Levosalbutamol was found to be more efficacious and safer than racemic salbutamol.
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Last modified: 2016-09-20 17:43:49