FABRICATION AND IN-VITRO CHARACTERIZATION OF TRANSDERMAL MATRIX PATCH OF KETOPROFEN FOR TRANSDERMAL THERAPEUTIC SYSTEM

Objective: The objective of research work was to improve the permeability of Ketoprofen and to provide controlled release of drug to provide maximum effective concentration. Experimental work: Transdermal drug delivery systems are polymeric patches containing dissolved or dispersed drugs that deliver therapeutic agents at a constant rate to the human skin. Matrix type transdermal patches containing Ketoprofen were prepared by solvent casting method employing aluminium foil method. Polyethylene glycol (PEG) 400 was used as plasticizer and Dimethyl sulfoxide (DMSO) was used as penetration enhancer. Polymers were selected on the basis of the their adhering and non-toxic property. Result and discussion Drug polymer interactions determine by FTIR and standard calibration curve of Ketoprofen were determine by using UV estimation. Transdermal patch was prepared by using HPMC K-4 M: PVP K-30, HPMC K-15 M: PVP K-30, HPMC K-100 M: PVP K-30, Eudragit RS-100:PVP K-30 showed good physical properties. All prepared formulations indicated good physical stability. In-vitro drug permeation studies of formulations were performed by using Franz diffusion cells using abdomen skin of Wistar albino rat. Result, showed best in-vitro skin permeation through rat skin (Wistar albino rat) as compared to all other formulations prepared with hydrophilic polymer containing permeation enhancer. The permeability of Ketoprofen was increased with increase in PVP content. The burst effect due to the incorporation of PVP was because of the rapid dissolution of the surface hydrophilic drug which gets swell and thus leads to the decrease of mean diffusional path length of the drug molecules to permeate into dissolution medium and higher permeation rates. Conclusion: It was observed that the formulation containing HPMC K-4 M: PVP K-30 (2:3) showed ideal higuchi release kinetics. Key words: Trasdermal drug delivery system, Polymers, Ketoprofen, Matrix type, Permiation.