SERUM URIC ACID LEVEL IN PRIMARY HYPOTHYROIDISM

Hypothyroidism is a clinical condition characterised by transient or progressive impairment of biosynthesis of thyroid hormones with compensatory thyroid enlargement. Thyroid hormone exerts its action on every cell of the body, by influencing the rate of general metabolic processes. It is involved in brain maturation and tissue development. Hyperuricemia can result from increased production or decreased excretion of uric acid or from a combination of two processes. In Primary hypothyroidism, renal plasma flow is reduced in accordance with the changes in cardiovascular hemodynamics that causes decreased glomerular filtration.AIM AND OBJECTIVES- The aim of the study is to estimate the level of Serum Uric acid in Primary hypothyroid cases and to compare it with normal, healthy control groups (age and sex matched) and to correlate the relationship between Serum Uric acid level with Serum Creatinine, Blood Urea, Total Cholesterol and fasting Glucose. MATERIALS AND METHODS: -Study population composed of 50 patients with Primary hypothyroidism and 50 healthy control groups (age and sex matched). Blood samples from both the groups were analysed for serum Uric acid, thyroid profile, renal function test, total cholesterol and fasting blood glucose. Uric acid was estimated by Uricase method. Thyroid profile was done by ELISA. RESULTS- The mean S.Uric acid level was significantly high in the study group (10.4 plus or minus 1.71 mgdl) when compared to the control group (5.37 plus or minus 0.95 mgdl) and the p value is statistically significant. Our study showed decreased level of S.T3 and S.T4 and increased S.TSH in the study group when compared to that of control group. CONCLUSION- To conclude, our study showed increased level of Serum Uric acid in patients with Primary Hypothyroidism when compared to normal healthy controls. Increase in S.Uric acid levels in hypothyroid patients may be due to increased production from excess ADP and decreased renal clearance If thyroid status is corrected, Uric acid level returns to normal and an improvement of renal status occurs in patients with Primary hypothyroidism.