EVALUATION OF CARDIOPROTECTIVE ACTIVITY OF ABROMA AUGUSTA ON ISOPRENALIN INDUCED MYOCARDIAL NECROSIS IN RATS

Myocardial infarction (MI) means that part of the heart muscle suddenly loses its blood supply. Without prompt treatment, this can lead to damage to the affected part of the heart. The present study was undertaken to study the cardioprotective effect of methanol extract of Abroma augusta leaves. The powdered crude leaves were extracted in a Soxhlet apparatus with methanol. Extract was dried at 40°C under pressure and stored at 4°C un til use. Phytochemical screening of extract was done by standard methods. Methanol extract of Abroma augusta was studied for acute oral toxicity according OECD guidelines No. 423 on Wistar rats. Isoprenalin induced myocardial necrosis in rats model was use d to study cardioprotective effect. After 10 days blood samples from animals were collected. Serum samples were analyzed for lactate dehydrogenase (LDH) and aspartate transaminase (AST) by using standard kits . The treatment with methanolic extract of Abrom a augusta significantly decreased the elevated levels of LDH, and AST as compared to control group. The present results indicated that the rats pretreated with Abroma augusta were significantly protected from myocardial damage caused by ISO may be due to the presence of flavonoids, polyphenols, alkaloids found in extract