THE METHOD OF ASSESSMENT OF DRUGS BELONGING TO THE SUBSTRATES OF P-GLYCOPROTEIN ON FEMALE RABBITS

The article describes the method of analysis of drugs belonging to the substrates of transporter P-glycoprotein (Pgp) on female Chinchilla rabbits which consisted in assessment of pharmacokinetics of a transporter-protein marker substrate (fexofenadine) before and after the introduction of its inductor (rifampicin 20 mg/kg of weight twice a day) and inhibitor (verapamil, 20 mg/kg three times a day). It is shown that verapamil administration cause fexofenadine accumulation in the rabbits and rifampicin ? did not significantly affect the drug pharmacokinetics, what doesn't allow to use for the developed analysis method. Thus, the definition of drugs belonging to the substrates of Pgp is advantageously carried out on male Chinchilla rabbits.