CD38 GENE POLYMORPHISM: EXPRESSION IN TUMOR FOCI OF COLON CANCER PATIENTS

CD38 is a multifunctional ecto-enzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. Single nucleotide polymorphism (SNP) rs6449182 CD38 gene polymorphism was determined by polymerase chain reaction with restriction of products in patients with colon cancer. Comparison of the genotypes of peripheral blood and tumor cells showed three of the tested patients were detected in heterozygote loss of tumor samples in which the allele G allele is replaced by C. The working hypothesis is that the presence of different alleles in colon cancer patients accounts for some of the clinical heterogeneity.