IMPACT OF ETHYL ETHER AND AMIDE 2- OXOINDOLIN -3-GLYOXYLIC ACID ON APOMORPHINE EFFECTS IN RATS

Neurotic disorders and depression play an important role in the structure of mental diseases and require an effective pharmacological correction. Dopaminergic system plays an important role in the pathogenesis of these diseases. The aim of the research is to study the influence of ethyl ester of 4-[2-hydroxy-2-(2-oxo-1,2-dihydro-indole-3-iliden)- acetomino] oil acid (E-38 substance) and amide 2-hydroxy-N-naphtalene-1-il-2(2-oxo-1,2-dihydro-indole-3-iliden) (substance 18) on apomorphine effects in rats. Materials and methods. Experiments were done on 60 white rats of Wistar. Ethyl ether and amide 2-oxoindolin (12 mg/ kg), imipramine (25 mg/kg) and diazepam (2 mg/kg) were administered intraperitoneally one hour prior to apomorphine administration (10 mg/kg). Latent period of stereotyped movements (sec.), duration (min.) and intensity (grades) were studied. Body temperature was also measured within 30 minute interval four-times. Results and discussion. Preventive administration of E-38 with apomorphine decreased the latent period 1,3 folds (<0,01) and significantly increased the total time of reactions compared with the administration of apomorphine only. Ethyl ether and amide 2-oxoindolin significantly prevented hypothermia at the 30th min and later, at the 60th min they intensified stereotypy 1,3 folds (р<0,05), at the 90th min they intensified it 1,9 folds compared with control pathology (р<0,01). Similar change of this parameter was noted at the 120th minute of the observation. E-38 did not affect apomorphine effects in experimental animals (rats). Conclusions. E-38 intensified apomorphine effects in rats. The activity of ethyl ether and 2-oxoindolin is compared with that of imipramine.