Hemin/G-Quadruplex Dnazyme for Electrochemical Biosensing

Guanine quadruplex (G-quadruplex) can bind tightly with hemin to form the hemin/G-quadruplex that displays robust peroxidase activity. Acting as a peroxidase-mimicking DNAzyme, hemin/G-quadruplex has been considered as a promising artificial enzyme for biosensing because of its low cost, high thermal stability as well as easy preparation and modification in the laboratory. Recently, hemin/G-quadruplex?based electrochemical biosensors have been successfully used for the detection of proteins, DNA, metal ions and small molecules. In this short review, we highlighted the recent advances of the design of strategies for the fabrication of hemin/G-quadruplex?based electrochemical biosensors.