LEYDIG CELL TUMOR IN CRYPTORCHID TESTIS

Leydig cell tumor of the testis is a rare(1-3 percentage), benign, interstitial tumor of sexcord stromal catgory.Cryptorchidism is a well established epidemiological risk factor of testiculargerm cell tumor.However,data regarding a possible association with Leydig cell tumor are scarce. Sofar only 20 cases of Leydig cell tumor in cryptorchid testis have been reported. Hereby, we present a rare case of Unilateral benign Leydig cell tumor in the cryptorchid testis. A 35 year old malepresented with a swelling in the right inguinal region for 2 months.CT abdomen revealed a tumorinvolving right ectopic undescended testis. Orchidectomy was performed. Grossly the tumor wasgray-brown, measuring around 8cm. Histopathologically, differential diagnosis of Leydig cell tumor,Testicular Tumor of adrenogenital syndrome(TTAGS), Leydig cell hyperplasia were considered.Immunohistochemical study was performed and tumor cells showed positivity for Inhibin A and serumadrenocorticotropic hormone (ACTH) level was within normal limits 23.80pg per ml(normal- 7.20-63.30pg per ml) postoperatively,confirming the diagnosis of Leydig cell tumor. This case has beenpresented for its rarity and to emphasize the importance of histopathologic features,immunohistochemical marker (Inhibin) and serum adrenocorticotropic hormone(ACTH) level forcorrect diagnosis since treatment protocol varies for different lesions.