Current Progress in Pediatric Inflammatory Bowel Disease

Recent progress in pediatric IBD studies reveals that genetic factors play an important role in pediatric IBD; mutations associated with VEO-IBD have been identified from IL10 and IL10 receptors; the IL10 gene and genes in IL10 pathway are identified to be associated with pediatric IBD, and epistasis interaction of SNPs/genes in IL10 pathway is shown to contribute to pediatric IBD. IL10 is an anti-inflammatory cytokine and the IL10/STAT3 signaling pathway plays an important role in controlling inflammation and homeostasis. IL10 is a target candidate gene for IBD clinical therapy.