Platelet and Acute Coronary Syndrome

Acute coronary syndrome (ACS) is a set of signs and symptoms due to rupture of a plaque and is a consequence of platelet rich coronary thrombus formation. Platelet parameters especially MPV could be an important and reliable markers in early detection of ACS when other markers are not available. This study was conducted in Department of medicine, in collaboration with Department of Cardiology, King George's Medical University. Total 296 adult (18 years above) patients with clinically suspected acute coronary syndrome who attended in cardiac emergency and admitted in coronary care unit (CCU) in the department of Cardiology were enrolled in this study. Comparing the mean of two groups (cases vs control), t test showed significantly (p<0.001) different and higher (MPV and PDW) while significantly (p<0.001) different in ACS case group compared to control group. Comparing the mean of two groups (cases vs control), t test showed significantly (p<0.001or p<0.05) different and higher (Hb and MCH) while significantly (p<0.001 or p<0.05) different in Control group compared to ACS cases group. In this research author reported that MPV had higher sensitivity and specificity in contrast to platelet count. MPV may used as predictor for early detection of ACS and risk stratification when other cardiac biomarkers are negative.