An Approach to Design and Development and Evaluation of Aceclofenac Floating Pellets Using Sodium Alginate and HPMC (HPMC K4M and HPMC K100LV) as polymer
Journal: International Journal of Innovation and Applied Studies (Vol.4, No. 2)Publication Date: 2013-10-02
Authors : Khanam Umme Hani; Paul Swati; Saha Dibyajyoti;
Page : 447-455
Keywords : Na-alginate; Aceclofenac; Methocel; Floating Pellet; Polymer;
Abstract
The present study was conducted to investigate the effect of Na-alginate and hydroxyl propyl methyl cellulose (HPMC) polymer combination of Aceclofenac floating pellets. The Aceclofenac pellets were prepared with two different grades of HPMC polymers in the ratio of 2:1, 1:2 and 1.5:1.5 respectively while the amounts of Na-alginate used in the formulations was 3.50, 5.25 and 7.0g. Prepared pellets were evaluated by Particle size and Morphology, Contraction ratio, Moisture content, Friability Test, Swelling study, Buoyancy time and floating time of the pellets were examined on the basis of polymer concentration. The contraction ratio of the particle was highest when pellets were prepared with 1.5% Na- alginate solution and the polymer ratio was 1:2 (BX, BY, BZ). In case of Buoyancy of Pellets, When Alginate concentration was 1% and HPMC K4M and HPMC K100LV ratio was 2:1 then, the Aceclofenac pellets were not floated for long time. When the concentration of Na-Alginate increased to 1.5%, 2%, then all pellets were floated. In case of swelling study, CY, BZ, CZ showed highest swelling of approximately 8% when Na-alginate concentration was (1.5 % , 2%, 2 %) and BY and CY batches showed lowest swelling of 2.9% at 4hrs when Na-alginate concentration was 1.5 %. Friability values for each formulation were recorded in table the values of the preferred formulas are within acceptable limit. Thus, the selection and use of suitable polymers in appropriate ratio is very important in designing floating pellets of Aceclofenac.
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