Pseudomonas chlororaphis subsp. Aureofaciens native AND MODIFIED BY COMPLEXES OF Ge(IV) AND Sn(IV) LIPOPOLYSACCHARIDE ANTIVIRAL ACTIVITY

The purpose of the research was to investigate changes of antiviral activity of Pseudomonas chlororaphis subsp. аureofaciens lipopolysaccharides (LPS) as a result of their modifications by coordination compounds of Sn(IV) and Ge(IV) synthesised on the basis of aromatic, pyridinecarboxylic acids hydrazides and appropriate hydrazones of aromatic aldehydes. A wide range of Ge(IV) and Sn(IV) coordinative compounds was chosen for P. chlororaphis subsp. аureofaciens UCM-306 LPS modification. ?Tobacco mosaic virus ? hypersensitive plant? model study of LPS and its modified preparations (1-35) antiviral activity showed that a lot of the tested preparations exhibit high antiviral activity due to their composition and structural peculiarities. Such preparations are of interest as perspective agents in struggle against plant virus diseases. Antiviral action of preparations (% of inhibition, I,%) which neutralizes virus infectivity, depends on: complexing metal [complexes of Sn(IV) are more active (I,% 65-79) as compared to Ge(IV) complexes (I,% 26-62)]; amount of functional groups in ligand molecules [hydrazone complexes of Sn(IV) are more active (I,% 69-79) then hydrazide ones (I,% 48-63)]; and also on coordination form of ligand coupling with different substituents [complexes with salicyloyl hydrazones of 4-mеtoxy- (I,% 71), 4-hydroxybenzaldehydes (I,% 77) and pyrogallol (I,% 72) with ketone O(C=O)?N(CH=N) form of a ligand are more active than with enol O(C-O)?N(CH=N) form of isonicotinoyl hydrazones of the same aldehydes (I,% 32-63)]. Introduction of two substituents (OH- and Br-) into the hydrazide fragment of hydrazone molecule significantly increases the activity of Sn(IV) complexes with enol form of the ligand (I,% 79).