PREFORMULATION AND PRELIMINARY STUDY ON THE USE OF NATURAL POLYMERS FOR THE DEVELOPMENT OF ORODISPERSIBLE TABLET USING CUT AND WEIGH METHODS

The complexity in the physicochemical characteristics of drugs and there In Vivo fate needs the quality of polymers to be that which could suppress the enzymatic action over drugs. The emergence of technology in an extraction procedure of herbal products has led to the development of various natural polymers which ensures the development of such dosage form that could easily deceive various factors affecting the degradation of drug within the body. The use of synthetic polymers in the formulation of orodispersible tablet was very common but high dispersion time, low hardness and failure in friability were the main reasons which led to the use of natural polymers like chitosan, gum tragacanth and gum karaya for the development of orodispersible tablet. But before formulation development the determination of preformulation studies as well as preliminary studies are main to carried down so, in this paper Preformulation studies of Venlafaxine hydrochloride for UV identification, solubility studies and lipophilicity was carried out. Similarly, preliminary studies of micromeritics properties and placebo formulations with their evaluation using cut and weigh methods were carried out. Keywords: Orodispersible tablets, Venlafaxine hydrochloride, gum karaya, gum tragacanth, Preformulation studies.