EVALUATION OF MURRAYA KOEINIGII LEAVES FOR NEUROPHARMACOLOGICAL ACTIVITY IN MICE

Researchers are developing drugs to treat many different neurological disorders even though plant based formulations usage is common thing in botanical remedies used universally. The present study is to evaluate pharmacological activity of Murraya koeinigii leaf extract against induced Neuronal disturbances and behavior alterations. Identification and extraction of the Murraya koeinigii plant has been done using aqueous and alcoholic solvents. Preliminary phytochemical studies were performed for chemical components of extracts. The Methanolic, Hydroalcoholic and Aqueous extracts of Murraya koeinigii, had been evaluated for the neuropharmacological action. The dose is determined by toxicity test and optimum safe concentration was 100mg/kg, 200 mg/kg body weight for the extract. Neuropharmacological profile is illustrated by Anxiolytic activity, Antistress, Antiepileptic, Depression induction by tail suspension, forced swim test, compulsive gnawing, Isoniazid induced epilepsy and Restrained stress. The effective doses are MEMK, HEMK, (200mg/kg) and AQMK(100mg/kg) has shown the moderate response. Hydroalcoholic extract is found to be more effective among all the three extracts in different concentrations. Hydroalcohlic fraction showed the presence of more percentage of Alkaloids and glycosides, had showed better neuropharmacololgical behaviour which can be inferred that the content in extracts is responsible for the activity. Keywords: Murraya koeinigii, Hydroalcoholic, Neuropharmacological, Anxiolytic, Antistress, Antiepileptic, Depression.