Synthesis and Antimicrobial Evaluation of some Novel Schiff Bases containing 1, 3, 4-Oxadiazole ring

The synthesis of benzylidene-(5-phenyl-[1,3,4]-oxadiazol-2-yl)amine (5) has been achieved by the reaction of Benzaldehyde(1) with Semicarbazide(2), it affords a Semicarbazone (3) which on fusion with glacial acetic acid and sodium acetate gives 5-phenyl-[1,3,4]-oxadiazol-2-yl-amine (4) which upon reaction with substituted Benzaldehyde gives benzylidene-(5-phenyl-[1,3,4]-oxadiazol-2-yl)amine derivative(5). All the synthesized compounds have been supported by spectral analysis. The antimicrobial activity of synthesized compounds has also been evaluated.