Clostridium Difficile Infection in Horses

Clostridium difficile (C. difficile) is the most common cause of antibiotic-associated diarrhoea and the etiologic agent of pseudomembranous colitis in humans. C. Difficile Infection (CDI) has also been associated with diarrhoea and colitis in many animal species. CDI in horses usually cause acute colitis, rapid weight loss with high mortality unless timely and effectively treated. However, little is known about how and why C. difficile induces severe disease in horses compared to other animals. This review will focus on CDI in horses.