“A rare case of Carbamazepine induced leucocytoclastic vaculitis and renal failure in a Diabetes mellitus patient”

Adverse effects due to carbamazepine occur in up to 25% of treated patients1,2. Hypersensitivity reaction comprises about 5% and include skin rashes, agranulocytosis, fever and abnormal liver function tests3 . Skin involvement complicating carbamazepine therapy is usually manifested by a variety of dermatoses including maculopapular, urticarial, erythematous and pruritic rashes. Lupus erythematosus-like diseases, exfoliative dermatitis and Stevens-Johnson syndrome have been reported rarely. The kidney is rarely involved. Water retention due to inappropriate secretion of ADH being most frequent adverse reaction. It is known to cause tubulointerstitial nephritis in the context of allergic reaction8 . Carbamazepine, as a cause of cutaneous vasculitis, is extremely uncommon4 .Carbamazepine-induced granulomatous necrotizing angiitis with acute renal failure has been reported. We report a Patient who developed hypersensitivity leukocytoclastic vasculitis, and renal failure followingthe administration of carbamazepine