FORMULATION AND EVALUATION OF ORAL SOFT JELLY CONTAINING GLIBENCLAMIDE
Journal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.03, No. 10)Publication Date: 2016-11-13
Authors : Kanika Nayak; Manoj Kumar Mishra; Garima Verma;
Page : 1276-1282
Keywords : Diabetes mellitus; Jelly; Dysphagia; Glibenclamide.;
Abstract
Convenience of administration and patient compliance are gaining significant importance in the design of dosage forms. Glibenclamide is an orally administered antihyperglycemic agent, used in the management of non-insulindependant (type-2) diabetes mellitus. Difficulty in swallowing (dysphagia) is common among all age groups, especially in elderly and pediatrics. Persons suffering from dysphagia may get choked when they consume liquid formulations, thus to alleviate such problem liquid formulation of high viscosity were prepared. Formulation of oral soft gel (batches of Glibenclamide) were prepared by using hydrophilic polymer guar gum at concentration ranging from 0.3-0.5% w/v and pectin at two different concentrations (0.2% and 0.3% w/v). The batch with 0.5% w/v guar gum and 0.2%w/v pectin not only showed 85% drug release after 1h. The prepared batches were evaluated for appearance, viscosity, pH, drug content, syneresis and in vitro drug release. The optimized batch showed substantial stability when subjected to short term stability study (0-8°C and at room temperature). The problem of dose measurement by patients was outweighed as oral medicated gels are to be packed in unit dose container. Keywords: Diabetes mellitus, Jelly, Dysphagia, Glibenclamide.
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