Autoimmune Progesterone Dermatıtıs durıng Pregnancy Results in a Full-Term Delivery

Autoimmune progesterone dermatitis (APD) is a rare disease that may first appear, worsen, or improve during pregnancy. We report a case of a 37-year-old primigravid woman who was referred to our clinic eight weeks pregnant with complaints of urticarial plaques on her lower extremities. As there were no obstetric complications, she was prescribed cetirizine (10 mg/day) treatment with follow-up. However, during the follow-up at 10 weeks gestation, she was admitted to the hospital with multiple aggravated erythematous lesions. Her symptoms were controlled with cetirizine (10 mg/day) and prednisone (40 mg/ day) together for one week. At 13 weeks gestation, she no longer had pain associated with cutaneous lesions, and, within one month, she noted a dramatic improvement in her urticaria. She had no further complaints, and delivered a 3,580-gram infant at 39 weeks gestation, with initial and 5 min Apgar scores of 8 and 10, respectively. The patient did not have any complications during the intrapartum or postpartum periods. These findings suggest that APD symptoms and attacks can be controlled or avoided during pregnancy with proper medication and follow-up.