Anti-c Antibody mediated Hemolysis - A Rare cause of Neonatal Jaundice

Neonatal jaundice caused by hemolytic disease of the newborn is mostly due to Rh(D), ABO incompatibilities and rarely due to other minor blood group incompatibilities. There are very few case reports of Minor blood group incompatibilities causing neonatal jaundice. We hereby report a neonate who had severe neonatal hyperbilirubinemia due to maternal anti-c antibodies leading to acute bilirubin encephalopathy. Though Minor blood group incompatibilities are a rare cause of neonatal hyperbilirubinemia, they should always be kept in mind while evaluating neonatal hyperbilirubinemia especially in situations where there is a positive direct coombs test and there is no Rh (D) or ABO incompatibility between the mother and the neonate.