Verrucous Carcinoma in Association with OSMF: A Rare Case Report

Verrucous carcinoma (VC) is a distinct variety of epidermoid carcinoma with pathognomonic clinical appearance, behavior and microscopic features. Verrucous carcinoma (VC) usually present with a hyperplastic epithelium with abundant keratin superficially is projecting as exophytic, church-spire keratosis and also, depicting parakeratin plugging which is believed to be characteristic of this tumor. The development of oral squamous cell carcinoma (OSCC) is seen in one-third of the oral sub mucous fibrosis (OSMF) patients but the development of verrucous carcinoma is rare in such patients. Herein, we are presenting a rare case report of verrucous carcinoma in a 26 year old male patient with OSMF who reported to the Outpatient Department with a chief complaint of an intra-oral growth in relation to left side of mouth since 4-5 years. On intraoral examination, an exophytic, broad-based, proliferative, papillary lesion measuring approximately 4x3cm was seen in relation to the left buccal mucosa. Also, blanching with a characteristic marble stone-like appearance was present in relation to right buccal mucosa and labial mucosa of the lower lip.