SOLUBILITY ENHANCEMENT OF VALSARTAN USING SOLID DISPERSION TECHNIQUE WITH NOVEL CARRIERS

Solubility is an important physicochemical factor affecting absorption of the drug and its therapeutic effectiveness. Drugs having poor aqueous solubility is one of the major confronts better absorption for good bioavailability of such drugs. The purpose of this study was to prepare and characterize solid dispersions of the poorly water soluble antihypertensive agent valsartan with water soluble carriers such as Kolliphor P 407, Kolliphor P 188, Kolliwax GMS II, HPMC AS and Soluplus in proportions viz. 1:1, 1:2, 1:3 (Drug: Carrier) to improving its aqueous solubility and rate of dissolution by solvent evaporation technique. All the formulations showed marked improvement in the solubility behavior and improved drug release. From all the formulations SD6 was found to be optimized formulation using soluplus as a carrier based on the solubility and dissolution studies. The results obtained showed that the aqueous solubility and rate of dissolution was significantly improved when formulated in solid dispersion as compare to pure drug. Keywords: