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A drug will not function unless it is bound to a receptor: a longstanding confusion in basic pharmacology

Journal: International Journal of Basic & Clinical Pharmacology (Vol.2, No. 6)

Publication Date:

Authors : ;

Page : 693-695

Keywords : Receptor-independent drugs; Osmotic diuretics; Keratolytic agent; Chelating agents; Surfactants; Antacid; Protectants and adsorbents; Sucralfate; Laxatives; Cholestyramine; NAC;

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Abstract

The disparity between the general definition of a ‘drug’ and the wide-spread mechanism of actions of receptor-dependent drugs may often mislead to believe that a drug-receptor interaction is always indispensable for a drug to exert its action. This short review is intended to rectify this basic misconception in pharmacology with the aid of a list of examples of several receptor-independent drugs in context to their mode of actions. [Int J Basic Clin Pharmacol 2013; 2(6.000): 693-695]

Last modified: 2013-12-16 02:12:56