MORPHOLOGICAL REACTIVITY OF RAT SPLEEN DURING DIFFERENT AGES AT IMMUNOSTIMULATION

I conducted the experiment on 180 white outbred male rats from three age periods (pubertal, reproductive and of expressed age-related changes) with the use of histological and morphometric methods. It was followed by statistical analysis. I pointed out that experimentally simulated activation of the immune system caused the morphological remodeling in the animal spleen. The manifestations were: increasing the area occupied by the white pulp and the size of the lymphoid follicles, widening the marginal zone and forming secondary follicles containing germinal centers. The highest level of spleen reactivity in response to the imunofan was observed in pubertal animals. Changes in the spleen white pulp of rats with expressed age-related changes took place against the background of involutive processes.