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Collagen-Albumin-Gentamicin Hydrogels Usable for Infected Wound Healing

Journal: Revista de Pielarie Incaltaminte / Leather and Footwear Journal (Vol.15, No. 4)

Publication Date:

Authors : ; ; ; ; ; ; ; ; ;

Page : 249-256

Keywords : hydrogels; collagen; rheology; albumin;

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The aim of this study was to develop new hydrogels for infected wound treatment. The main components of hydrogels were two proteins, one fibrous (type I collagen in the form of gel) and one globular (albumin) in different ratios (10, 20 and 30%), and gentamicin was selected as an antibiotic drug model. The properties of the obtained hydrogels were estimated by rheological measurements and the corresponding lyophilized forms by water up-take capacity. The results showed that the promising hydrogels which can provide good absorbance and antimicrobial properties at the same time are the ones with maximum 20% albumin and 0.2% gentamicin and the in vitro tests are further recommended.

Last modified: 2017-03-03 18:47:36