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Aqueous Bark Extracts of Terminalia Arjuna Stimulates Insulin Release, Enhances Insulin Action and Inhibits Starch Digestion and Protein Glycation in Vitro

Journal: Austin Journal of Endocrinology and Diabetes (Vol.1, No. 1)

Publication Date:

Authors : ; ; ; ;

Page : 1-6

Keywords : Terminalia arjuna; diabetes; insulin; glucose uptake.;

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Scientific evidence for the effects of Terminalia arjuna on diabetes mellitus is lacking. This study investigated the anti-diabetic efficacy and mode of action of the bark extract of Terminalia arjuna. Insulin-release from BRIN-BD11 cells was assessed in the absence or presence of T. arjuna extracts and modulators of insulin-secretion. Insulin concentration and intracellular calcium ([Ca2+]i) were measured by radioimmunoassay and FLEXstationTM respectively. Adipocyte glucose-uptake with 3T3-L1 fibroblasts, starch digestion with α?amylase and protein glycation were assessed in vitro. Terminalia arjuna extract stimulated insulin-release alone (p<0.001), in combination with known modulators but not without extracellular Ca2+. It increased intracellular calcium but had no effects on depolarised cells. Glucose-uptake was enhanced in the presence of T. arjuna (P< 0.001). At higher concentrations, the extract decreased starch digestion and inhibited protein glycation (p<0.001). Terminalia arjuna extract possesses antidiabetic potential and may provide new opportunities for the treatment of diabetes.

Last modified: 2017-03-10 18:43:13