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Pre-exposure to Fine Particulate Matters may Induce Endotoxin Tolerance in a Mouse Model

Journal: Austin Journal of Environmental Toxicology (Vol.1, No. 1)

Publication Date:

Authors : ; ; ; ; ;

Page : 1-4

Keywords : Lipopolysaccharides; Fine particulate matters; Survival curves; Heat-shock response;

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Exposure to low or moderate doses of Lipopolysaccharides (LPS) renders the host tolerance to a subsequent lethal dose of LPS, which is termed as endotoxin tolerance. It is characterized as the decrease in production of pro-inflammatory cytokines and the increase in production of anti-inflammatory mediators in response to subsequent LPS challenge. Whether other environmental factors also trigger endotoxin tolerance remains unclear. Both epidemiologic and experimental studies have provided a link between particulate matters and human health. Here, we speculated on the effect of fine particles priming on endotoxin tolerance in a mouse model.

Last modified: 2017-03-14 19:03:55