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Journal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.04, No. 03)

Publication Date:

Authors : ; ; ;

Page : 651-669

Keywords : Solid-self nanoemulsifying drug delivery system; Pseudo ternary phase diagram; Bioavailabilit; solubility; permeability.;

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Developments in recent drug discovery programs, yields a large proportion of novel pharmacologically active molecules that are lipophilic and poorly soluble ,which is a major challenge for pharmaceutical researchers to enhance the oral bioavailability of such drug molecules. Compared to conventional oral dosage forms, Self nanoemulsifying drug delivery systems (SNEDDS) possesses potential advantages like ease of manufacture and scale up, quick onset of action, reduction in drug dose, reduction in inter and intra subject variability and food effects and minimize problems associated with filling of liquid SNEDDS in capsules. Several recent works on Self nanoemulsifying drug delivery systems suggests the commercial suitability of the system in improving the solubility and bioavailability of such drugs. The physicochemical properties, drug solubilization capacity and physiological fate considerably helps in the selection of the SNEDD components. The composition of the SNEDDS can be optimized mainly with the help of phase diagrams, whereas statistical experimental design can be used for further optimization. The transition of liquid SNEDDS to solid SNEDDS has also been accomplished by researchers. Solidself nanoemulsifying drug delivery system focus on the incorporation of liquid/semisolid self nano emulsifying ingredient into solids by different solidification techniques like adsorption to solid carrier, spray drying, melt extrusion, nanoparticle technology and melt granulation. The present article gives more specification on spontaneous/rapid forming nanoemulsions or self nanoemulsifying systems for oral drug delivery by adsorption technique and gives complete information about formulation, method of preparation, characterization and application in solid dosage form of self nanoemulsifying drug delivery system. Keywords:Solid-self nanoemulsifying drug delivery system , Pseudo ternary phase diagram, Bioavailabilit,solubility,permeability.

Last modified: 2017-04-09 23:43:15