THE EFFECTS OF DEXMEDITOMIDINE ON PERIOPERATIVE HEMODYNAMICS IN CRANIOTOMY

OBJECTIVE In this prospective randomized placebo controlled study, we investigated the effects of Dexmeditomidine as an adjuvant in craniotomy on the following hemodynamic changes and brain edema during the perioperative period, and additional opioid requirement.MATERIALS AND METHODS Twenty patients of ASA physical status and undergoing craniotomy were randomly divided into two groups as Group D (Dexmeditomodine group) and group P (placebo group). In the Group D (n10), Dexmeditomidine was infused as bolus dose of 1microgram per kg over 10 minutes before induction of anaesthesia, maintained with 0.4-0.5microgram per kg per hour during the surgery and stopped at the initiation of skin suture. At the time of induction, fentanyl was given as a 2microgram per kg dose in both the groups. Hemodynamic changes, cerebral relaxation scores, and additional intraoperative opioid requirement were recorded. RESULTS In Group D, HR and MAP values were significantly lower than the placebo group after induction