FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF METOPROLOL SUCCINATE

In the present work efforts have been made to develop fast dissolving tablets of Metoprolol succinate using direct compression technique involving super disintegrants like cross povidone, sodium starch glycolate. The pre compression parameters like angle of repose, bulk density, true density, compressibility index are within the IP limit. The post compression parameters are acceptable and within the IP limit. In-vitro drug release at for all the formulations was found to be 95 to 99% and was satisfactory. The optimized formulation (F6,10%cross povidone) of drug release was found to be is 99% at 30 min. Key words: fast dissolving tablets, Mouth Dissolving Drug Delivery System and Metoprolol succinate