Neuroprotective Effect of Chlorogenic Acids against Alzheimer’s Disease

With increasing trend of aging population, neurodegenerative diseases, including Alzheimer's Disease (AD) have become more prevalent in today's society. Coffee is a popular beverage that has been linked to health benefits, including the potential to mediate AD. Coffee contains different concentrations and isomers of chlorogenic acids (CGAs), which represent a group of phenolic compounds abundant in human diet that have garnered interest due to their antioxidant activity in relation to neurological benefits. Evidence supporting the neuroprotective effects of CGAs has been observed in epidemiological studies, as well as in vitro and in vivo studies. CGAs are capable of mediating oxidative stress and attenuating cell apoptosis due to different oxidative stressors and free radicals by modulating the accumulation of reactive oxygen species and by regulating the expression of key proteins and enzymes involved in cell apoptosis. As CGAs are highly bioavailable in humans compared to other bioactive polyphenols, these compounds have the potential to exert positive effects in alleviating AD.