Preparation and Evaluation of Ethosomal Gel of Clotrimazole for Fungal Infection by Mechanical Dispersion Method

The present study investigates the use of ethosomal formulation of clotrimazole by mechanical dispersion method. In this work initially ethosomes of clotrimazole were prepared by using different concentration of soya lecithin and then optimized formulation batch was selected by determining Size and surface morphology , drug entrapment efficiency (DEE),in vitro release study and the best formulation was used to prepare gel by using carbopol 934 as a gelling agent . pH and Viscosity were determined of Ethosom entrapped gel. The formulated ethosomal gel obtained was exploited to achieve a zero order release profile of Clotrimazole. DEE was obtained between 52.6 to 60% in best formulations This study disclosed that RE5∗ was the best promising formulation among all prepared formulations.