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A simple UV Spectrophotometric method for Quantitative Estimation of Enalapril maleate

Journal: Current Research in Pharmaceutical Sciences (Vol.6, No. 1)

Publication Date:

Authors : ; ; ; ;

Page : 21-26

Keywords : Enalapril maleate; spectrophotometry; ICH guidelines; oxidation; potassium permanganate;

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A simple UV spectrophotometric method is described here to analyze enalapril maleate in bulk and dosage forms. The method is based on oxidation of enalapril maleate with potassium permanganate and sulphuric acid. The reaction is followed by measuring the absorbance at 267 nm. Beer's law is obeyed in the concentration ranges of 250-500 μg ml-1, respectively. The method has been applied to the determination of enalapril maleate in bulk. Results of analysis are validated statistically and as per ICH guidelines. The method is found to be specific, repeatable, accurate and precise.

Last modified: 2017-06-05 20:08:26