Synthesis and Biological Evaluation of Quinazolinone Fused Chalcone Derivatives as Anti-inflammatory AgentsJournal: Current Research in Pharmaceutical Sciences (Vol.4, No. 1)
Publication Date: 2014-03-31
Authors : Nancy Jain; Nimisha Jain; P K Singour;
Page : 15-20
Keywords : ;
In the present study we have designed a new pharmacophore by pharmacophore hybridization approach of drug design. Quinazolinone nucleus has potent anti-inflammatory activities with nearly negligible ulcer index unlike other non steroidal anti-inflammatory drugs. Chalcone also have anti-inflammatory activity. Therefore, here we had tried to synthesize some of the novel quinazolinone fused chalcone derivatives and tested them for their anti-inflammatory activity. The structures of the compound have been confirmed by spectral analysis. Newly synthesized compounds were tested for anti-inflammatory activity using Rat hind paw method. Among the synthesized compounds 3-[1-(3, 4-dimethoxyphenyl)-3-(3-nitrophenyl) allylideneamino]-2-phenylquinazolin-4(3H)-one (4) were found to be most active.
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