Formulation and Evaluation of Salicylic Acid and Urea Gel for Treatment of PsoriasisJournal: Current Research in Pharmaceutical Sciences (Vol.2, No. 3)
Publication Date: 2012-09-30
Authors : Ishan Dubey; Rajesh K Jatav; Shailendra S Patel; Rakesh K Jatav; Rajendra V Sheorey;
Page : 166-170
Keywords : ;
Gel containing salicylic acid and urea with five different proportions of carbopol polymer were prepared. These formulations were studied for pH, drug content, viscosity, spreadability, extrudability, skin irritation studies, in-vitro studies and stability studies. The formulated gel F3 shows pH 7.0, drug content 85 % and 89 % of salicylic acid and urea respectively, viscosity 10000 cps, spreadability24.6 gm.cm/sec, extrudability 75.1 %, no skin irritation, in-vitro drug release of salicylic acid and urea were found to be 71 % and 81 % respectively. After stability studies of formulation F3, all the above datas comes in acceptable range.
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