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QSAR on Heteroaryl-Phenyl-Substituted Pyrazole Derivatives as Selective and Potent Canine COX-2 Inhibitors

Journal: Current Research in Pharmaceutical Sciences (Vol.1, No. 2)

Publication Date:

Authors : ; ; ;

Page : 68-76

Keywords : ;

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A series of heteroaryl-phenyl-substituted pyrazole derivatives was subjected to QSAR analysis and the equations generated thereof showed good correlation between COX-2 inhibitory activity and physico-chemical as well as steric properties of the derivatives. One of the significant equations generated has a r value of 0.859 and cross validated r2 (q2) value of 0.534. The contributing parameters include Connolly Accessible Area (CAA), Principal Moment of Inertia at z-axis (PMZ) and Partition Coefficient (PC). Keywords: COX-2, QSAR, steric parameters, physicochemical properties, regression, statistical validation

Last modified: 2017-06-06 21:25:42