Formulation and Evaluation of Nano Copper Gel For Treatment of Clinical Mastitis

Clinical mastitis is considered to be a sizeable clinical problem in dairy industry. Apart from cows it is also reported in sheep and even in breast feeding mothers. Staphylococcus aureus bacteria accounts for infections to a great extent and its control is a vital part in curing programs. Metal nano copper has gathered much attention in antifungal/antimicrobial applications. In the present work Carbapol-934 gel, infused with nano copper was formulated and evaluated, which can be a remarkable breakthrough in the field. The antimicrobial test on nano copper against Staphylococcus aureus and Escherichia coli proved the antimicrobial property of the former. The prepared gel was evaluated for PH, homogeneity, spreadability, drug content, in-vitro drug release and ex-vivo permeation. The accelerated stability studies and rheological studies were also conducted. The results of above tests were encouraging for the evolution of the above gel to cure clinical mastitis.