Distribution and Estimation of Imatinib Loaded Pegylated PPI Dendrimeron BDF1 Hybrid Mice-Bearing K-563 Acute Lymphoblastic Leukemia

The Pharmacokinetics (PK) and Bio Distribution (BD) of Imatinib loaded PEGylated PPI dendrimer formulations with different drug release rates were studied on BDF1 hybrid mice-bearing k-563 acute lymphoblastic leukemia. Imatinib is an efficacious anticancer drug with a spectrum of potential antitumor applications limited by poor bio distribution at therapeutic concentrations, so Imatinib loaded PEGylated PPI dendrimer was assessed for pharmacokinetic distribution profile of PEGylated PPI dendrimer holding Imatinib. Its single dose (6.25 mg kg-1) was administered i.v. to male micebearing k-563 acute lymphoblastic leukemia. Imatinib concentration was measured in spleen, liver, kidney and lung using a HPLC assay. These findings encourage the development of novel Imatinib formulations to treat other cancers.Estimated the bio-distribution of Imatinib in different vital organ was carriedout by HPLC method and the study was promising the distribution of drug candidate.