EVALAUTION OF ANTIHYPERLIPIDEMIC ACTIVITY OF TEPHROSIA PURPUREA PLANT EXTRACTS IN MICE

In this work the cold extraction process was done with the help of methanol. About 200gms of powdered material was taken in a clean, flat bottomed glass container and soaked in 750 ml of methanol. The container with its contents were sealed and kept for period of 7 days accompanied by continuous shaking with the shaker. The whole mixture then went under a coarse filtration by a piece of a clean, white cotton wool.Investigation revealed the presence of Alkaloid, Tannin, Saponin, Phenol in Methanolic Extract of Tephrosia purpurea while only Phenol were present in Phenolic Extract of Tephrosia purpurea The results of the study clearly indicate that METP Extract and PETP Extract at a dose of 500 mg/kg & 400 mg/kg significantly lowered serum lipid levels (P<0.01). PETP Extract at a dose of 500 mg/kg significantly lowered serum lipid levels, (P<0.001) i.e. antihyperlipidemic activity which was found to be more effective in higher dose of PETP as compared to METP and lower dose of PETP when administered orally in triton induced hyperlipidemic models.The results concluded that PETP (500 mg/kg) have definite antihyperlipidemic activity in Triton X-100 induced hyperlipidemic model and which is equipotent activity when compared with Atorvastatin treated groups. Further studies on this extract may lead to identify the possible mechanism of action and isolation of active principle from the same. Keywords: Tephrosia purpurea, Antihyperlipidemic activity