CHALLENGES IN NANOTECHNOLOGY DRUG DELIVERY SYSTEMS - STATE OF ART TECHNOLOGIES

The potential challenges to solve the poor solubility, limited chemical stability in vitro and in vivo after administration (i.e. short half-life), poor bioavailability and potentially strong side effects requiring drug enrichment at the site of action (targeting). This review describes the use of nanoparticulate carriers, developed in our research group, as one solution to overcome the dosage forms. The performance of ODTs depends on the technology used in their manufacture. The orally disintegrating property of these tablets is attributable to the quick ingress of water into the tablet matrix, which creates porous structure and results in rapid disintegration. Hence, the basic approaches to develop ODTs include maximizing the porous structure of the tablet matrix, incorporating the appropriate disintegrating agent and using highly water-soluble excipients in the formulation. Fast disintegrating tablets have better patient acceptance, compliance and possibly will tender enhanced biopharmaceutical properties, superior efficacy, and enhanced safety compared to conventional oral dosage forms. The perspective for such dosage forms is promising because of the accessibility of new technologies combined with strong market/patient acceptance. Keywords: Oro dispersible tablets, Bioavailability, Conventional films, Disintegrating time