Pharmacological and Anticarcinogenic Effects of Grape Seed Extract : A Comprehensive Review

Breast Cancer is a carcinoma of breast tissues, the major recurrent cancer in women worldwide and also the foremost cause of death. Dietary intake of antioxidant rich foods is protective against cancer. Antioxidant rich food include grape (Vitis vinifera,family:Vitiaceae). one of the world's largest fruit crops and consumed commonly in the world.The major phenolic antioxidant composition in Vitis viniferae extracts are discussed in this review.The Resveratrol is the main biologically active constituent of grape which is known to produce medicinal properties in human diseases. Grape seed extracts exert free radical scavenging activities and inhibit lipid oxidation invitro cell line studies and also Invivo tumor studies. Grape seed as a antioxidants are effective against a broad range of cancer cells which target epidermal growth factor receptor (EGFR) and E2 receptors, resulting in cell cycle arrest and apoptosis. Grape seed extracts have great potential in the prevention of cancer and further investigation for this study field is needed.