FORMULATION AND EVALUATION POLYHERBAL FORMULATIONS FOR PEDICULOCIDAL AND ANTI DANDRUFF ACTIVITYJournal: Journal of Drug Sciences (Vol.1, No. 1)
Publication Date: 2013-08-24
Authors : Sandhya S Prathyusha V Vinod K.R David Banji;
Page : 15-21
Keywords : Pediculus humanus; Malassezia furfur; nymphs; nits; diffusion.;
The present work is envisaged on a comparative evaluation of three hair preparations incorporated with extracts of four herbs which has a claim of pediculocidal and antidandruff activity. Equal quantities of extracts of four herbs namely; Cyclea peltata leaf, Datura inoxia seeds, Tigonella foenum graecum leaf and Vigna mungo seeds were taken and formulated into a 1% hair lotion, hair oil and hair cream. The evaluation parameters performed were organoleptic studies, pH, diffusion studies, stability studies, drug content, viscosity and skin irritation test. The three formulations passed all the evaluation parameters performed. The pH obtained was matched with that of the skin pH. All the formulations were found to be stable as there were no much change in the globule size, moisture absorbance and phase separation. Viscosities of all the formulations were in the normal ranges which in turn help in easy removal of the formulations when the indented activity is attained. It was observed that 1% PHHL has shown maximum pediculocidal and antidandruff activity when compared to 1% PHHO, 1% PHHC. The potency of 1%PHHL is due to the high diffusion rates, penetration and drug content. The pediculocidal and antidandruff activity potency can be endorsed to alkaloids, flavonoids and saponins present in the extract.
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