FORMULATION AND DEVELOPMENT OF LAMIVUDINE ANTI HIV MATRIX TABLETSJournal: Journal of Drug Sciences (Vol.2, No. 1)
Publication Date: 2014-01-24
Authors : Ashok Kumar.P Arkendu Chatterjee; David Banji;
Page : 1-5
Keywords : Lamivudine; AIDS; Eudragits 100; Eudragitl-100 Direct Compression;
In Present Research Work To Develop Lamivudine Extended Tablets For Prolong Release and Increased Gastric Retention Time. Lamivudine Is the Approved Compound For The treatment of AIDS; However the Main Limitation to Therapeutic Effectiveness of Lamivudine Is Its Dose dependent Toxicity, Short Biological Half-Life and High Bioavailability. Fourier Transform Infrared Spectroscopy That No Interactions between drug, polymer and excipients. Tablets Were Prepared By Direct Compression Method Using Different Polymers Eudragit S 100 And Eudragitl-100 are different excipients and different concentration of polymers containing F1-F9 Formulation In Different Ratio Of Polymers and different evaluation parameter Hardness thickness, weight variation friability and optimised formulation F6 And Drug Release Is 99.37% , Its Is Due To Increase Polymer Concentration and Release of drug follows first Order and It was shown non fickians (case-II) (anomalous) transport diffusion mechanism.
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Last modified: 2014-01-30 15:50:13