SYNTHESIS, CHARACTERISATION AND INVITRO ANTIBACTERIAL SCREENING OF NOVEL THIAZOLE ANALOGUES

Thiazole containing N=C-S moiety exhibit broad spectrum of biological activities like fungicidal, antimicrobial, antitubercular activities and thiazole possess biological activities like bactericidal, antifungal, analgesic, antiinflammatory, diuretic, CNS depressant and anticancer activity. Recent literature reports explore the biological importance of thiazole analogues as antibacterial agent. The aim and objective of the present investigation is to develop novel thiazole analogues. In this study 3 novel thiazole analogues were synthesised by Schiff's reaction of 2-amino-4-phenylthiazole with substituted aromatic aldehydes. The puriy of newly synthesized compounds was ascertained by consistency in the TLC as well as melting point determination and were characterised by means of IR spectral analysis. Antibacterial screening was carried out using pour plate agar diffusion method and was tested against Bacillus subtilis, Staphylococcus aureus, E.coli, Pseudomonas aureginosa using Ciprofloxacin (100 µg/ml) as standard drug. Compound T1 exhibited significant activity towards gram positive organism and T2 exhibited significant activity towards gram negative organism when compared to standard drug Ciprofloxacin and others show moderate activity. Finally it was concluded that novel thiazole analogues can be considered as the future lead molecule for drug discovery process. Key words: Thiazole analogues, Schiff's reaction, IR spectral analysis, Anti bacterial screening, Pour plate agar diffusion method.